SVA Elements Are Nonautonomous Retrotransposons that Cause Disease in Humans

Genetic Mutations that Cause Coronary Artery Disease

SVA retrotransposons as modulators of gene expression

Endogenous mobile genetic elements can give rise to de novo germline or somatic mutations that can have dramatic consequences for genome regulation both local and possibly more globally based on the site of integration. However if we consider them as "normal genetic" components of the reference genome then they are likely to modify local chromatin structure which would have an effect on gene re...

SVA retrotransposons as potential modulators of neuropeptide gene expression

Many facets of human behaviour are likely to have developed in part due to evolutionary changes in the regulation of neuropeptide and other brain-related genes. This has allowed species-specific expression patterns and unique epigenetic modulation in response to our environment, regulating response not only at the molecular level, but also contributing to differences in behaviour between indivi...

SVA elements: a hominid-specific retroposon family.

SVA is a composite repetitive element named after its main components, SINE, VNTR and Alu. We have identified 2762 SVA elements from the human genome draft sequence. Genomic distribution analysis indicates that the SVA elements are enriched in G+C-rich regions but have no preferences for inter- or intragenic regions. A phylogenetic analysis of the elements resulted in the recovery of six subfam...

that are present at birth in humans

P<P Published online August 23, 2012 in advance of the print journal. Preprint Accepted preprint is likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; License Commons Creative . http://creativecommons.org/licenses/by-nc/3.0/ License), as described at under a Creative Commons License (Attribution-NonCommercial 3.0 Unporte...